FreeBSD is known to have a very low default file handle limit. Start the server by using the --open-files-limit option for mysqld_safe, or raise the limits for the mysqld user in /etc/login.conf and rebuild it with cap_mkdb /etc/login.conf. Also be sure that you set the appropriate class for this user in the password file if you are not using the default (use chpass mysqld-user-name).
If you have a lot of memory, you should consider rebuilding the kernel to allow MySQL to use more than 512MB of RAM. Take a look at option MAXDSIZ in the LINT config file for more information.
If you get problems with the current date in MySQL, setting the TZ variable should help.
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